Insulin resistance and aldosterone.

Two doctors familiar with my case are convinced that my insulin resistance will go away as soon as the aldosterone overproduction is stopped, whether it is by surgery or eplerenone. I don’t want to get my hopes up, but – what can I say, my hopes are up 🙂

Here are a few relevant articles on the relationship between aldosterone and insulin resistance and/or Type 2 diabetes:

Role of aldosterone and angiotensin II in insulin resistance: an update (link opens PDF)

There is abundant evidence linking aldosterone, through non-genomic actions, to defective intracellular insulin signalling, impaired glucose homeostasis and systemic insulin resistance not only in skeletal muscle and liver but also in cardiovascular tissue.

Insulin Sensitivity in Patients with Primary Aldosteronism: A Follow-Up Study

Conclusions: Insulin resistance is present in patients with tumoral and idiopathic aldosteronism, but the defect appears less severe than in patients with essential hypertension. Treatment with surgery or aldosterone antagonists restores rapidly and persistently normal sensitivity to insulin.

Salt, aldosterone, and insulin resistance: impact on the cardiovascular system (link opens PDF)

Current clinical knowledge points towards an impact of salt restriction, RAAS blockade, and MR antagonism on cardiovascular and renal protection, but also on improved insulin sensitivity and glucose homeostasis.

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